自闭症谱系障碍扰乱了儿童发育期间大脑网络连接性成熟的过程
Lattika Tiawongsuwan1, Sumeth Klomchitcharoen1, Wachiraya Chumanee1
1Brain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, 73170, Thailand.
Scientific reports
|December 1, 2025
概括
这项研究揭示了自闭症谱系障碍 (ASD) 儿童中大脑网络通信中断和大脑发育的改变. 这些发现提供了对自闭症病理学的见解,并可能指导未来的干预措施.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 生物医学工程 生物医学工程
背景情况:
- 自闭症谱系障碍 (ASD) 在理解发育轨迹方面存在重大挑战,阻碍了早期干预.
- 确定可靠的自闭症生物标志物对于改善诊断准确性和治疗策略至关重要.
研究的目的:
- 与神经类型儿童相比,研究ASD1级儿童的大脑成熟轨迹.
- 探索脑电图 (EEG) 生物标志物,包括α功率,峰值α频率和转移,以检测发育差异.
主要方法:
- 在休息状态下,利用脑电图 (EEG) 对35名ASD一级儿童和35名神经类型儿童进行了测试.
- 分析了对α功率,峰值α频率和转移的群体差异和与年龄相关的变化.
主要成果:
- 在患有自闭症的儿童中,观察到大脑定向网络通信的显著中断.
- 在ASD组中发现了尾α功率和峰值α频率的变化.
结论:
- 这项研究强调了自闭症谱系障碍中大脑成熟的发育障碍.
- 这些发现为自闭症病理机制提供了宝贵的见解,并支持开发新的干预策略.
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