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患有急性缺血性中风患者的血管内皮生长因子-A和附带循环,原因是内大血管封闭
Ana Aguilera-Simón1,2, Marina Guasch-Jiménez3,4, Francisco Moniche5
1Cerebrovascular Diseases Group, Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, Barcelona, 08041, Spain.
Translational stroke research
|December 1, 2025
概括
较高的血管内皮生长因子-A (VEGF-A) 血水平与接受内血管治疗 (EVT) 的急性缺血性中风 (AIS) 患者的更好的附带循环 (CC) 有关. 这种关联表明VEGF-A可能会影响AIS中的担保功能.
科学领域:
- 神经科学是一个神经科学.
- 心血管医学 心血管医学
- 生物化学 生物化学
背景情况:
- 附带循环 (CC) 对于管理中风进展至关重要.
- 血管内皮生长因子-A (VEGF-A) 是血管新生的一个关键调解者.
- 了解VEGF-A和CC之间的关系对于急性缺血性中风 (AIS) 患者至关重要.
研究的目的:
- 研究AIS患者血VEGF-A水平与附带循环 (CC) 之间的关联.
- 评估接受内血管治疗 (EVT) 的大血管封闭 (LVO) 患者.
主要方法:
- 一项前性多中心研究,涉及290名用EVT治疗的LVO-AIS患者.
- 在入院时测量血VEGF-A水平.
- 使用CT血管造影的自动附带评分来评估CC (分类为0-3,二分化为差0-1和好2-3).
- 多变量后勤回归分析以确定VEGF-A和CC之间的关联.
主要成果:
- 较高的VEGF-A基线水平独立地与更好的CC相关 (cOR=1.83,p=0.007).
- 一个VEGF-A值<14 pg/mL识别了75.2%的特异性,与良好的CC相反相关 (aOR=0.53,p=0.036).
- 在VEGF-A水平和3个月功能结果之间没有发现显著的关联.
结论:
- 循环中的VEGF-A水平与AIS患者的CC状态独立相关,前部LVO患者接受了EVT治疗.
- 这些发现表明,VEGF-A与附带功能之间存在潜在的生物联系.
- 观察到的关系应被解释为关联,而不是因果关系.
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