预后营养指数和功能性结局在患有下关节出血的患者:一个元分析
Sha Luo1, Qiuyan Xiang1, Muhammad Masroor Hussain2
1Department of Intensive Care Medicine, West China Hospital, Sichuan University, No.37, Guoxue Lane, Wuhou District, Chengdu, 610041, China.
Neurosurgical review
|December 1, 2025
概括
通过营养指数识别的入院时的营养不良与动脉瘤下arachnoid出血 (SAH) 患者功能恢复的恶化有关. 早期营养评估对于改善SAH后患者的治疗结果至关重要.
科学领域:
- 神经学 神经学
- 营养科学 营养科学
- 临界护理医学 临界护理医学
背景情况:
- 营养不良是一个重要的,但往往被低估的因素,影响神经复苏后下关节出血 (SAH).
- 营养指数如预后营养指数 (PNI),控制营养状况 (CONUT) 评分和老年营养风险指数 (GNRI) 是潜在的预后标志物.
- 这些营养标志物与动脉瘤SAH (aSAH) 患者的功能结果之间的关联需要进一步澄清.
研究的目的:
- 进行一项元分析,评估aSAH患者入院营养不良和功能不良结果之间的关系.
- 评估PNI,CONUT和GNRI在预测aSAH后功能恢复方面的预后价值.
主要方法:
- 进行了观察性队列研究的元分析.
- 研究包括aSAH患者,通过低PNI,高CONUT或入院时低GNRI评估营养不良.
- 功能性不良结局被定义为修改的兰金尺度≥3或格拉斯哥结局尺度≤3. 几率比率 (ORs) 和95%置信区间 (CI) 使用随机效应模型进行了聚合.
主要成果:
- 分析了6项涉及1048名患者的研究.
- 入院营养不良与功能性结果差的几率增加显著相关 (OR: 1.64;95% CI: 1.24-2.16).
- 在PNI,CONUT和GNRI中观察到一致的关联,在男性占主导地位的队列和3个月的随访时,联系更强.
结论:
- 营养指数显示的入院营养不良与动脉瘤SAH患者的功能不良结果有显著的关联.
- 入院时的营养状况是SAH后功能恢复的关键预测因素.
- 这些发现强调了营养评估和干预在治疗aSAH患者中的重要性.
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