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脂肪感官线索在生命早期的程序中对食物和肥胖的中心反应
Laura Casanueva Reimon1,2, Ayden Gouveia1,2, André Carvalho1,2
1Max Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany.
发育过程中高脂肪饮食 (HFD) 的感官线索,而不仅仅是卡路里,可以为后代在以后的生活中代谢不灵活和肥胖进行编程. 这通过改变大脑对食物的反应而发生,影响饥饿信号.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 发展生物学 发展生物学
背景情况:
- 孕产妇的肥胖是众所周知的后代代谢疾病的风险因素.
- 饮食的感觉方面在编程后代代谢健康中的作用,独立于热量含量,尚未完全理解.
研究的目的:
- 调查发育期间高脂肪饮食 (HFD) 的非营养感官成分是否会改变后代的代谢健康.
- 确定与脂肪相关的感官线索影响中央食欲调节和新陈代谢的机制.
主要方法:
- 们被养成异营养,培根口味的饮食,富含与脂肪相关的气味.
- 后代在成年后被评估代谢健康,脂肪和神经反应 (多巴胺基电路,阿古蒂相关 (AgRP) 神经元).
- 测试了新生儿感官电路激活和被动气味暴露,以及与热量摄入相结合的感官刺激.
主要成果:
- 对与脂肪相关的气味的发育暴露导致了代谢不灵活性,并在成年后期养HFD的后代增加了脂肪.
- 这些影响独立于母亲的代谢健康.
- 暴露改变了中层多巴胺循环,使AgRP饥饿神经元对食脂肪变得不敏感.
- 综合的感官刺激和热量摄入加剧了肥胖.
结论:
- 在发育过程中HFD的感官成分可以为代谢功能障碍的后代编程.
- 与脂肪相关的感官线索作为发育信号,启动中央食欲调节和新陈代谢.
- 了解这些感官通路对于预防饮食相关的代谢疾病至关重要.
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