一个儿科病例严重的细菌中枢神经系统感染成功地用连续的腹腔脊柱排水治疗
Satoshi Kitamura1, Kohei Kanaya2, Kotaro Nakamura1
1Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
概括
连续输入肠道的抗生素 perfusion 成功治疗了耐火性细菌性脑膜炎和水脑的儿科病例. 这种救援疗法实现了完全的神经恢复,避免了永久的脑脊液转移.
科学领域:
- 儿童传染病 儿童传染病
- 神经临界护理是指神经临界护理.
- 抗生素治疗 抗生素治疗
背景情况:
- 儿童中枢神经系统 (CNS) 的细菌感染具有重大风险,特别是在抗生素耐药性或脑脊液 (CSF) 动态受损的情况下.
- 一名14岁的男孩经历了严重的中枢神经系统并发症,包括脑膜炎,腹腔炎和水头炎,来自Streptococcus intermedius感染,对标准治疗无反应.
研究的目的:
- 评估连续的腹腔内-腰部内抗生素输液的疗效,作为耐药儿科中枢神经系统感染的救援疗法.
- 评估该方法的安全性和潜力,以实现统一的抗生素分配和恢复CSF循环.
主要方法:
- 患者接受了连续的腹腔内腰部内抗生素输液,使用万科米辛和珍塔米辛.
- 这种方法旨在确保稳定的抗生素水平,并通过双排水保持稳定的CSF流量.
主要成果:
- perfusion 疗法导致了渐进的放射学和临床改善.
- 患者在随访期间实现了完全的神经恢复,没有复发.
结论:
- 连续双排水输液是一种潜在的有效和安全的救援策略,用于复杂的儿科中枢神经系统感染.
- 这种创新方法可以在耐火的情况下提供替代永久CSF转移的替代方案.
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