与药物分类的ATC系统相关的问题
Lilly Josephine Bindel1, Roland Seifert2
1Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Naunyn-Schmiedeberg's archives of pharmacology
|December 1, 2025
概括
解剖治疗化学品 (ATC) 分类系统存在重要的结构和术语问题. 提出的以机制为导向的系统为现代药物治疗和药物利用研究提供了更为一致的框架.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物使用研究 药物使用研究
- 医疗信息学 医疗信息学
背景情况:
- 解剖治疗化学品 (ATC) 分类系统是药物利用研究的全球标准.
- 尽管ATC系统被广泛使用,但它存在结构和概念上的局限性.
- 这些限制影响了药物使用数据的准确性和一致性.
研究的目的:
- 评估ATC分类系统的一致性,完整性和术语.
- 识别系统的弱点,并提出潜在的改进或替代方案.
- 评估ATC系统适用于现代药物治疗的适用性.
主要方法:
- 使用"ATC/DDD指数2025"和世卫组织"2025指南"对所有14个ATC主要组和子级进行系统分析.
- 检查分类逻辑,治疗领域覆盖范围,组合产品的处理和术语.
- 在ATC组内和跨ATC组之间的差异的记录.
主要成果:
- 在ATC系统的分类逻辑中发现了广泛的不一致性,混合了解剖学,治疗,药物学,化学和各种原则.
- 组合产品和具有多种适用性药物的不适当处理会导致碎片化,重叠和重复.
- 模糊或过时的术语掩盖了药理学机制,反映了历史而不是科学理由.
结论:
- 空中交通管制分类系统显示有系统的缺陷,阻碍了准确的药物使用分析.
- 它的现有结构不适合当代药物开发,多征兆药物和合理的处方.
- 建议基于药理性质和分子标的机械面向系统,以获得更一致和更适应的框架.
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