在尼日利亚拉各斯的住院患者中,与细菌相关的血液感染
Christopher Oladimeji Fakorede1, Kehinde O Amisu2, Kabiru Olusegun Akinyemi3
1Department of Biological Sciences, Microbiology Unit, Lagos State University of Science and Technology, Ikorodu, Lagos, Nigeria. fakorede.co@lasustech.edu.ng.
BMC infectious diseases
|December 1, 2025
概括
这项研究发现,尼日利亚患者中高患有导致血流感染 (BSI) 的グラム阴性细菌. 多种药物耐药性显著,特别是在Proteus和大肠杆菌中,与严重的症状和临床诊断有关.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 细菌性血液感染 (BSI) 是一个主要的健康问题,特别是在低收入和中等收入国家.
- 诊断延迟和抗菌素耐药性加剧了这些地区的BSI结果.
研究的目的:
- 在尼日利亚拉各斯的住院发烧患者中调查BSI的患病率,临床因素,细菌原因和耐药性模式.
主要方法:
- 从五个医疗保健中心 (2018-2023) 的发烧住院患者收集了2,940个血液样本.
- 用标准的微生物学和质谱学来识别细菌.
- 根据CLSI指南进行了抗微生物敏感性测试,并进行了统计分析.
主要成果:
- 10.44%的样本是培养阳性; 91.8%是グラム阴性细菌.
- 蛋白质种类,大肠杆菌和克莱布西拉种类. 是最常见的病原体.
- 败血症,心肌梗塞,极端年龄组和临床诊断与BSI有很强的相关性 (p < 0.0001).
- 多种药物耐药性在Proteus vulgaris (32.7%) 和大肠杆菌 (27.9%) 中很高.
结论:
- 由于尼日利亚的Proteus,大肠杆菌和Klebsiella引起的格兰阴性BSI的高负担.
- 在关键病原体中观察到显著的多药耐药性.
- 骨关节炎与临床指标如败血症,心肌梗塞,极端年龄和临床诊断有很强的关联.
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