与巴西圣保罗死产相关的因素:FetRiskS - 一项多学科病例控制研究
Lays Janaina Prazeres Marques1, Gizelton Pereira Alencar1, Dario Ezequiel Elias1
1Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo, 715 - Cerqueira César, São Paulo, 01246-904, Brazil.
BMC pregnancy and childbirth
|December 1, 2025
概括
在巴西,死胎的危险因素包括缺乏伴侣,吸烟,不充分的产前护理,高血糖,胎盘病变,胎儿生长限制和先天性形. 这些发现凸显了中等收入国家死产的复杂特征.
科学领域:
- 周围生理学 周围生理学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 死产是一个主要的全球公共卫生问题.
- 许多因素导致死产,包括社会经济,人口,环境,行为,医疗保健和生物因素.
- 了解这些风险因素对于制定有效的预防策略至关重要,特别是在中等收入国家.
研究的目的:
- 调查与巴西圣保罗死产相关的特定风险因素.
- 确定导致中等收入环境中死产的关键母婴和胎儿决定因素.
主要方法:
- 一项基于人口的病例控制研究在巴西圣保罗的14家公立医院进行.
- 病例包括死胎,对照组包括活产.
- 数据收集包括对母亲的采访,医院记录,产前护理登记,以及对感染生物标志物的胎盘和母体血液样本的分析,利用逻辑回归来确定几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 这项研究分析了401例死产和419例活产.
- 确定死产的重大风险因素包括:没有伴侣 (OR=1.76),怀孕期间吸烟 (OR=1.94),不充分获得产前护理 (OR=2.15),高血糖 (OR=1.91),胎盘病变 (OR=3.15),胎儿生长限制 (OR=6.16) 和先天性形 (OR=4.25).
结论:
- 这项研究突出了中等收入国家背景下死产风险因素的复杂概况.
- 已识别的孕产妇和胎儿因素是预防死产的关键目标.
- 这些发现强调了需要综合护理,解决社会,行为和生物决定因素的需要.
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