刺激性肠综合征的结果措施:一个范围审查
Jia-Hao Mo1, Ping Zeng1, Li-Lei Zhou1
1The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, China.
在刺激性肠综合征 (IBS) 随机对照试验 (RCT) 中选择适当的结果措施对于准确的疗效评估至关重要. 本研究组织了IBS RCT结果,以指导对未来研究进行更好的选择.
科学领域:
- 胃肠病学 胃肠病学
- 临床试验 临床试验
- 肠-大脑相互作用障碍 肠-大脑相互作用障碍
背景情况:
- 刺激性肠综合征 (IBS) 是一种常见的肠脑疾病.
- 目前的随机对照试验 (RCT) 往往缺乏结果选择的理由,这可能会阻碍有效性评估.
研究的目的:
- 系统地组织来自IBSRCT的结果信息.
- 将结果分类为领域,并确定测量工具.
- 将措施按治疗机制,IBS亚型分类,研究旨在改善选择.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行系统的文献搜索,截至2023年5月.
- 结合"IBS"和"RCT"的搜索术语,并提供信息专家的输入.
- 将结果和工具分类为领域,按IBS亚型和干预分层.
主要成果:
- 分析了408项研究;结果包括总体改善 (76.96%),个体症状 (64.46%),生活质量 (43.63%) 和心理状态 (24.26%).
- 关键工具:IBS-SSS,BSFS,IBS-QOL,HADS. 这些都是我们所知道的.
- IBS亚型表现出特定的症状焦点 (例如,在IBS-C中压力,在IBS-D中紧迫性);在药物试验中,心理领域的评估是有限的;长期复发率被低估.
结论:
- 以药物机制,IBS亚型和研究目标为指导的适当的结果测量选择,提高了疗效评估.
- 在IBSRCT中对安慰剂效应和长期结果评估需要进一步关注.
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