尼科兰迪尔对接受冠状动脉干预的患者功能的保护作用:系统性审查和元分析
Ahmed A Abo Elnaga1, Ibrahim Saleh Alawadi1, Abdelrahman M Elettreby2
1Faculty of Medicine, Mansoura University, Mansoura, Egypt.
BMC nephrology
|December 1, 2025
概括
尼科兰迪尔有效地降低了对比诱导性病 (CIN) 的发生率和心脏干预患者的肌素升高. 该药物表现出良好的安全性,使其成为脏保护的有希望的选择.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
背景情况:
- 对比诱导性病 (CIN) 具有很大的风险,特别是在接受心脏手术的慢性病患者中.
- 评估CIN的预防策略对于改善干预性心脏病学的患者结果至关重要.
研究的目的:
- 评估尼科兰迪尔在接受冠状动脉干预的患者中预防对比诱导性病 (CIN) 的疗效.
- 确定尼科兰迪尔对功能标记物的影响,包括血清肌素和估计的淋巴球过率 (eGFR).
主要方法:
- 一个系统的审查和随机对照试验 (RCTs) 的元分析,发表到2024年9月.
- 纳入标准侧重于评估尼科兰迪尔在接受冠状动脉手术的患者中预防CIN的疗效的研究.
- 分析了涉及2837名患者的11项试验的数据.
主要成果:
- 尼科兰迪尔显著降低了CIN发病率 (RR = 0.37,P < 0.001),没有异质性.
- 在干预后24,48,72小时观察到血清肌素水平显著降低 (P < 0.01).
- 在尼科兰迪尔和对照组之间,没有发现eGFR或主要心血管不良事件的显著差异.
结论:
- 尼科兰迪尔在减少CIN发病率和急性损伤标志物方面表现出显著的有效性.
- 该药物具有良好的安全性,没有增加重大不良事件的风险.
- 尼科兰迪尔代表了一种有价值的治疗选择,用于在接受冠状动脉干预的患者中保护脏.
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