瑞士菌鸟类扩张表明共享抗生素使用驱动主机跳跃
Muriel Dresen1,2, Gemma G R Murray3, Peter Valentin-Weigand4
1Department of Veterinary Medicine, Institute of Microbiology and Epizootics, Freie Universität Berlin, Berlin, Germany. muriel.dresen@fu-berlin.de.
BMC biology
|December 2, 2025
概括
在牲畜中共用抗生素可能会推动多药耐药性Streptococcus suis (S. suis) 在猪和家禽之间传播. 这可能导致适应和传播给野生鸟类,扩大病原体范围.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗微生物耐药性 抗微生物耐药性
- 一个健康 一个健康
背景情况:
- 新出现的传染病,如抗菌素耐药性,与人类,动物和环境健康有关.
- 猪和家禽是多药耐药细菌的储存库,包括动物性病原体Streptococcus suis (S. suis).
- 在家禽中S. suis的存在引发了关于细菌在物种之间传播和适应的问题.
研究的目的:
- 为了研究宿主跳跃和适应多药耐药性Streptococcus suis (S. suis) 进入鸟类种群.
- 在鸟类中区分S. suis的暂时溢出和持续宿主适应.
主要方法:
- 对来自不同宿主的3000多个S. suis分离物的基因组分析.
- 遗传学分析以确定宿主跳跃事件.
- 对不同宿主中的细菌存活率和基因组含量进行比较分析.
主要成果:
- 一个独特的多药耐药的S. suis血统,与主要的动物传染病血统分开,反复跳入鸟类.
- 有证据表明,S. suis适应了鸟类,包括基因组变化和鸟类血液中的增强生存.
- 观察到从家禽传染到野生鸟类,这表明进一步传播.
结论:
- 在猪和家禽中共用抗生素可能会促进多药耐药S. suis.的宿主跳跃.
- 虽然可能不是动物传播的S. suis的主要来源,但牲畜使用抗生素可以促进病原体向新宿主传播.
- 这扩大了抗微生物耐药细菌病原体的生态范围.
更多相关视频
相关概念视频
Antibiotic Selection
59.3K
Overview
59.3K
Viral Recombination
24.9K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
24.9K
Development of Antibiotic Resistance
1.2K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.2K
Horizontal Gene Transfer
1.3K
Horizontal gene transfer (HGT) is a process where genetic material moves between organisms within the same generation, unlike vertical gene transfer, which occurs from parent to offspring. HGT plays a crucial role in microbial evolution, adaptation, and survival, particularly in shared environments like the human gut.Mobile genetic elements such as plasmids, prophages, integrons, insertion sequences, and transposons facilitate this process. HGT occurs through three primary mechanisms:...
1.3K
Transduction
1.1K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
1.1K
Gene Regulation in Microbial Communities: Quorum Sensing
473
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
473


