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酶在核酸纳米技术中的功能和应用

Qinze Rong¹, Zibin Chu¹, Ye Xu¹

¹State Key Laboratory of Organic-Inorganic Composites, Beijing Key Laboratory of Bioprocess, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.

Journal of nanobiotechnology

|December 2, 2025

概括

酶通过使可编程分子组装和动态控制成为可能,显著增强了核酸纳米技术 (NAN). 本综述对酶及其作用进行了分类,为先进的酶驱动纳米设备铺平了道路.

科学领域:

生物技术和纳米技术
分子生物学分子生物学
生物化学生化学

背景情况:

核酸纳米技术 (NAN) 是一个可编程的平台,具有多样化的应用.
现有的审查集中在无酶NAN上,在理解涉及酶的系统方面留下了一个空白.
酶为NAN提供了增强的可编程性,动态控制和多功能性.

研究的目的:

系统地分类NAN中使用的酶工具包.
阐明酶在结构组装和动态控制中的作用.
为酶驱动的NAN建立一个统一的概念框架.

主要方法:

酶的分类:聚合酶,修饰酶,核酶,联酶,核酸酶 (DNA酶, рибо酶,XNA酶).
酶功能的阐明:组装,降解,释放,模板引导的聚合.
复习由酶驱动的NAN应用的进展.

主要成果:

酶在NAN中充当组装剂和驱动工具.
酶集成导致适应性,可重新配置的系统超过无酶NAN.
突出了诊断,成像,数据存储,材料和药物输送方面的关键进展.

结论:

酶对于先进的NAN至关重要,提供了卓越的控制和功能.
将催化机制映射到功能输出提供了一个设计路线图.
未来的方向包括解决下一代纳米设备的特异性,模块化和集成方面的瓶.

关键词:

在DNA纳米结构中.酵素酶是一种酶.核酸纳米技术核酸纳米技术核酸反应网络中的核酸反应网络.

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