在重症患者中诊断和治疗侵袭性候群病:SIAARTI多学科陈述
Andrea Cortegiani1,2, Gennaro De Pascale3,4, Giulia De Angelis3,5
1Department of Precision Medicine in Medical, Surgical, and Critical Care, University of Palermo, (Me.Pre.C.C.), Via del Vespro 129, Palermo, 90127, Italy. andrea.cortegiani@unipa.it.
Journal of anesthesia, analgesia and critical care
|December 2, 2025
概括
危急病患者面临侵袭性候群病 (IC) 的高风险. 新的指导方针为ICU的诊断和管理提供了针对患者的量身定制方法,旨在降低重症监护病房 (ICU) 的死亡率.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 在重症监护室 (ICU) 的重症患者容易患入侵性角膜炎 (IC).
- 延迟诊断和不理想的IC治疗导致高死亡率.
- 在ICU中需要标准化,针对患者量身定制的IC管理策略.
研究的目的:
- 制定基于共识的陈述,用于诊断和管理严重病患者的IC.
- 为临床医生提供一个实际的框架,以改善IC病例的决策.
- 解决IC护理的关键方面,包括风险因素,生物标志物和抗真菌疗法.
主要方法:
- 意大利麻醉,止痛,复苏和重症监护学会 (SIAARTI) 召开了一个多学科专家小组 (密集医生,传染病专家,微生物学家,药理学家).
- 专家小组通过专家讨论和协议制定了13份基于共识的声明.
- 声明涵盖了风险因素识别,生物标志物的实用性,抗真菌选择 (PK/PD,特定于地点) 和治疗药物监测 (TDM).
主要成果:
- 在13份共识声明中,IC诊断和管理的关键方面得到了解决.
- 提供了关于识别IC风险因素和利用生物标志物的治疗决策的指导.
- 建议包括使用药理动力学/药理动力学 (PK/PD) 原则和TDM优化抗真菌选择,并特别考虑特定的解剖部位.
结论:
- 开发的陈述提供了一个实用,多学科的框架,用于管理危急病患者的IC.
- 实施这些指导方针可以改善临床决策,并可能减少与IC相关的死亡率.
- 该共识解决了从风险分层到优化抗真菌治疗和监测的关键要素.
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