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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
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Updated: Jan 9, 2026

Trace Fear Conditioning in Mice

Trace Fear Conditioning in Mice

Published on: March 20, 2014

在背景恐惧调节后,海马区域CA1复杂多脊柱发作的衰老独立减少.

Raquel Martinez-Serra¹, Suji Lee¹, Igor Kraev²

¹Department of Basic and Clinical Neuroscience, King's College London, London, UK.

Molecular brain

|December 2, 2025

概括

此摘要是机器生成的。

多内尔化树突 (MISs) 在老年小鼠中有助于记忆. 意想不到的是,在年轻和老老的小鼠中,多脊柱结节 (MSB) 复杂性在恐惧调节后降低,这表明它在记忆回忆中发挥了作用.

关键词:

衰老的衰老衰老的衰老在海马体内,海马体记忆记忆记忆记忆记忆多突触激活器的激活器

更多相关视频

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

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Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

相关实验视频

Last Updated: Jan 9, 2026

Trace Fear Conditioning in Mice

Trace Fear Conditioning in Mice

Published on: March 20, 2014

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

科学领域:

神经科学是一个神经科学.
突触性可塑性突触性可塑性
记忆研究记忆研究

背景情况:

持久的突触变化对于记忆存储和回忆至关重要.
之前的研究已经在老老鼠的记忆形成后发现了多内内化树突 (MIS).
多脊柱 (MSBs) 在记忆回忆中的作用仍然不清楚.

研究的目的:

在情境恐惧条件化 (CFC) 后,研究多脊柱结节 (MSB) 复杂性的变化.
为了确定老化是否影响MSB复杂性的变化后CFC.
探索MSB复杂性在记忆回忆中的潜在作用.

主要方法:

重新分析现有的三维电子显微镜图像.
在CFC后24小时内对海马CA1层辐射体的超结构分析.
在年轻和老年小鼠中对MSB复杂性的比较.

主要成果:

在CFC.24小时后,CA1层辐射体中MSB复杂性意外下降.
这种MSB复杂性的降低在年轻和老年小鼠中都被观察到.
衰老没有影响MSB复杂性的观察到的变化.

结论:

在CFC之后,MSB复杂度的降低而不是增加,发生在CFC之后.
这种突触变化独立于年龄.
减少MSB复杂性可能是恐惧调节后特定记忆回忆的关键.