5岁以下儿童急性腹中肠道病原体的同时感染和相互作用:中国的一项大型多中心观测研究
Shun-Xian Zhang1,2, Qin-Yan Zuo1, Jin-Xin Zheng2
1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Infectious diseases of poverty
|December 2, 2025
概括
与肠道病原体的同时感染在腹的儿童中很常见,而A组轮状病毒 (RVA) 显著加剧了疾病的严重程度. 接种RVA疫苗对于减少儿童的腹负担和疾病严重程度至关重要.
科学领域:
- 儿童传染病 儿童传染病
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 腹是五岁以下儿童的主要健康问题,肠道病原体发挥着关键作用.
- 了解病原体相互作用及其对腹严重性的影响至关重要,但尚未确立.
研究的目的:
- 研究共同感染肠道病原体之间的相互作用及其对腹病原体的影响.
- 分析儿童肠道病原体共感染的流行病学框架.
主要方法:
- 这是一项大规模的多中心病例控制研究,在中国广州的四家三级医院进行.
- 从5岁以下的腹和非腹儿童收集便样本.
- 确定了21种肠道病原体,并使用添加和乘法模型评估了相互作用.
主要成果:
- 肠道病原体在腹儿童中 (53.6%) 检测的频率高于对照组 (27.8%).
- 在腹儿童 (16.1%) 和对照 (4.5%) 中,同时感染的发生率明显高.
- 对于RVA+DEC,RVA+CD,RVA+NoVs GII和DEC+Bh发现了协同作用,RVA在加剧严重程度方面发挥了核心作用.
结论:
- 与肠道病原体的同时感染在腹儿童中很常见,并且可以协同相互作用.
- 组A轮状病毒 (RVA) 在加剧并发感染的严重性方面发挥着核心作用.
- 强调RVA疫苗接种对于减少儿童腹的负担和严重程度至关重要.
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