探讨慢性冠状动脉综合征上社会心理因素的因果途径和调解效应:孟德尔的随机化研究
Xiaotong Li1, Yan Wang2, Chunhua Song3
1Second School of Clinical Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Medicine
|December 2, 2025
概括
焦虑,抑郁和腹增加慢性冠状动脉综合征 (CCS) 的风险,而较高的家庭收入减少了这一风险. 这些社会心理因素通过涉及炎症,脂质和吸烟的遗传途径影响CCS.
科学领域:
- 遗传学和流行病学
- 心血管疾病研究研究
- 精神病体医学是一种精神病体医学.
背景情况:
- 慢性冠状动脉综合征 (CCS) 是一个复杂的疾病,具有多因素的起源.
- 社会心理社会因素越来越多地被认为对心血管健康的潜在影响.
- 了解这些关联的遗传基础对于有针对性的干预至关重要.
研究的目的:
- 使用遗传变异视角研究社会心理社会因素和CCS之间的因果关系.
- 确定这些因素影响CCS风险的调解途径.
- 探索遗传倾向在心理健康,社会经济地位和心脏病之间的联系中的作用.
主要方法:
- 门德尔的随机化 (MR) 方法利用遗传变异作为工具变量.
- 分析社会心理因素,包括焦虑,抑郁,腹和家庭收入.
- 应用R软件包 (TwoSampleMR,MR-PRESSO,MVMR) 和因果估计的逆方差权重.
- 识别涉及与TNF相关的诱导亡联体 (TRAIL),LDL,甘油三 (TG) 和吸烟启动的调解途径.
主要成果:
- 焦虑,抑郁和腹与CCS有显著的积极因果关联.
- 较高的家庭收入表明与CCS有显著的负因果关系.
- 识别的调解途径包括通过吸烟启动,TRAIL,LDL和TG影响焦虑/抑郁/收入的CCS.
结论:
- 焦虑,抑郁和腹等社会心理社会因素与增加的CCS风险有因果关系.
- 家庭收入较高与CCS风险降低有关.
- 这些关联部分是由生物途径介导的,包括炎症,脂质代谢和吸烟行为,为预防和治疗提供了洞察力.
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