萨科佩尼亚指数与患有功能障碍的老年人中跌倒风险的关联:基于查尔斯数据的队列研究
Jiamin Duan1, Changlin Li, Yuting Li
1Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, Zhejiang Province, China.
Medicine
|December 2, 2025
概括
麻症指数 (SI) 可能有助于确定患有脏问题的老年人中跌倒风险. 较高的SI与较少的跌倒有关,特别是在肥胖患者中,这表明它可以用于预防策略.
科学领域:
- 老年学是指老年学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物 生物标志物
背景情况:
- 功能障碍在老年人中很常见,并且与跌倒风险增加有关.
- 来自血清肌素和细胞素C的肉类症指数 (SI) 是肌肉健康的潜在指标.
- 在功能受损的个体中,SI与跌倒风险之间的关联存在有限的研究.
研究的目的:
- 为了研究缩症指数 (SI) 和中年和老年人患有功能障碍的跌倒风险之间的关系.
- 确定特定的子组,如肥胖患者,他们可能从SI评估下降风险中获益最多.
- 评价SI作为一个实用的生物标志物,用于在这个人群中预防跌倒的策略.
主要方法:
- 来自中国健康与退休长度研究数据的二次分析 (2011年基线,2015年后续).
- 包括3461名功能受损的参与者 (eGFR<90mL/min/1.73m2).
- 使用血清肌素和细胞素C计算SI;通过自我报告评估跌倒;使用多变量逻辑回归和受限立方线模型进行统计分析.
主要成果:
- 较高的SI四分位数与降低跌倒风险有关 (Q2-Q4与Q1:调整后的OR为0.75-0.54).
- 在SI和跌倒风险之间没有观察到显著的剂量反应关系 (P=0.312).
- 在肥胖的参与者中,较高的SI对跌倒的明显保护作用被注意到 (OR0.57,P相互作用=0.039).
结论:
- 麻症指数 (SI) 与功能受损的老年人中跌倒风险相反相关.
- SI可以作为一种有价值的生物标志物,用于识别有较高跌倒风险的个体,特别是那些肥胖的人.
- 这些发现支持在临床实践中基于SI评估开发有针对性的跌倒预防策略.
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