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免疫细胞和血代谢物对炎症性肠病的影响:双样本孟德尔随机化研究和调解分析

Zhong Li¹, Haiyan Wen², Xueyun Huang³

¹Department of Geratology, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China.

|December 2, 2025

概括

这项研究使用了门德尔的随机化来发现免疫细胞,代谢物和炎症性肠道疾病 (IBD) 之间的因果关系,包括性结肠炎 (UC) 和克罗恩氏病.

科学领域:

免疫学免疫学免疫学
代谢学代谢学代谢学
胃肠病学胃肠病学

背景情况:

炎症性肠病 (IBD) 涉及与免疫相关的胃肠道炎症.
免疫机制和代谢因素显著影响IBD的发展和进展.
在IBD中免疫和代谢因素之间的相互作用尚未完全理解.

研究的目的:

研究免疫细胞表型,血代谢物和IBD之间的因果关系.
识别免疫细胞与IBD联系的途径中的潜在介导代谢物.
为了探索IBD亚型的这些关联:性结肠炎 (UC) 和克罗恩病 (CD).

主要方法:

采用了两个样本的孟德尔随机化 (MR) 分析.
评估了731种免疫细胞类型,1400种血代谢物和IBD (包括UC和CD) 之间的关联.
使用逆变量加权,简单模式,加权中位数和加权模式方法,使用MR-Egger回归来测量质性,Cochran的Q测试来测量异质性,以及对灵敏度的留出一项分析. 进行中介分析以确定中间代谢产物.

主要成果:

确定了17种免疫细胞表型和37种与IBD因果相关的代谢物 (P < .01).
发现了13种免疫细胞表型和15种与UC相关的代谢物,以及11种免疫细胞表型和19种与CD相关的代谢物.
已经证明了特定的介导途径,例如,阿拉基多酸盐到油酸盐到酸盐的比率介导CD25在IgD+CD38br和IBD上 (7.42%的介导).

结论:

确立了特定免疫细胞表型和与IBD,UC和CD的血代谢物之间的因果关系.
提供了关于IBD免疫和代谢因素的复杂相互作用的新见解.
建议预防,诊断和管理IBD的潜在目标.

关键词:

门德尔的随机化免疫细胞是免疫细胞.炎症性肠病是一种炎症性肠病.调解分析调解分析血代谢物的血代谢物

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