黄素对类风湿性关节炎患者的炎症标志物和疾病活性的影响:元分析
1Department of Rheumatology and Immunology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Hainan Hospital, Haikou, Hainan, China.
Medicine
|December 2, 2025
概括
黄素补充剂显著改善了类风湿性关节炎 (RA) 疾病活性和炎症标志物. 需要进一步的研究来确认临床使用的长期益处.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 自然产品研究自然产品研究
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性炎症性疾病.
- 黄中的一种化合物黄因其抗炎性质在RA中受到研究.
- 目前关于黄素在 RA 中有效性的证据是不一致的.
研究的目的:
- 评估黄素补充剂对 RA 患者疾病活性的影响.
- 为了评估系统性炎症标志物的变化,在RA中使用黄素.
- 通过对随机对照试验的元分析来综合当前的证据.
主要方法:
- 在PubMed,科克伦图书馆,科学网和Embase的系统文献搜索到2025年8月.
- 包括随机对照试验 (RCT),将黄素与安慰剂或成人RA患者的标准治疗进行比较.
- 使用Cochrane风险偏差2.0进行数据提取和质量评估;与审查经理和统计数据进行聚合分析.
主要成果:
- 七个RCT被纳入了元分析.
- 黄素显著降低了28个关节的疾病活性评分,类风湿性因素,红细胞沉积率和C反应蛋白.
- 敏感性分析证实了聚合估计的稳定性,没有发现显著的出版偏差.
结论:
- 库尔库明补充剂在RA疾病活动和炎症方面显示出统计和临床显著的改善.
- 黄素显示出作为类风湿性关节炎的辅助治疗的前景.
- 更大的试验验证暴露和更长的随访是必要的,以确认长期影响和指导临床应用.
相关概念视频
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
457
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
457
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
461
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
461
01:11Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K
01:20The JAK-STAT Signaling Pathway
11.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
11.8K
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
413
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
413
01:28Inflammatory Response
15.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.9K