临床实践指南,用于评估和管理Sjögren病中周围神经系统表现的临床实践指南
Anahita Deboo1, Robert Fox2, Katherine M Hammitt3
1Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Arthritis care & research
|December 2, 2025
概括
本指南提供基于证据的建议,用于评估和管理Sjögren病患者的外周神经系统 (PNS) 问题. 它有助于临床医生和患者在诊断和治疗方面做出明智的决定.
科学领域:
- 类风湿病学 类风湿病学
- 神经学 神经学
- 临床实践指南 临床实践指南
背景情况:
- 斯约格伦病是一种自身免疫性疾病,影响多个器官系统,包括周围神经系统 (PNS).
- 在Sjögren病中PNS的参与可以表现为单独神经病变,多神经病变和自主神经病变.
- 临床实践指南对于管理像Sjögren病这样的复杂疾病至关重要.
研究的目的:
- 制定基于证据的临床实践指南,用于评估和管理Sjögren病中PNS表现.
- 为患者和医疗保健提供者提供决策资源.
- 标准化PNS参与Sjögren病的命名法和最佳实践.
主要方法:
- 在2025年7月22日之前,使用PubMed和Embase进行了对文献的系统审查.
- 一个由风湿病学,神经病学和指南专家组成的主题审查小组 (TRG) 开发了PICO问题.
- 文献选,数据提取和批判性评估是重复进行的,只有有限的高级别证据被确定.
主要成果:
- 为PNS术语建立了一个一致的命名体系.
- 开发了31种评估疑似PNS表现的最佳实践.
- 制定了20个基于证据的治疗建议,使用GRADE方法进行评分,主要基于专家意见,因为证据稀缺.
结论:
- 本指南提供了一个严格的,基于证据的资源,用于评估,诊断和治疗Sjögren患者的外围神经病变.
- 当好处明显超过危害时,推被评为强大,指导患者首选行动.
- 该指南是通过专家基于共识的过程制定的.
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