化纳米材料通过调节eicosanoid脂质信号传导来触发人类支气管上皮细胞中的免疫调节效应
Govind Gupta1, Jonas Bossart1,2,3, Sènan Mickael D'Almeida4,5
1Swiss Federal Laboratories for Materials Science and Technology (Empa), Laboratory for Particles-Biology Interactions, St. Gallen, 9014, Switzerland.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 2, 2025
概括
暴露于六角化 (h-BN) 和化纳米管 (BNNTs) 改变细胞膜脂质并触发免疫反应. 这凸显了BN纳米材料的潜在健康风险,特别是对于免疫功能受损的个体.
科学领域:
- 纳米材料的毒理学
- 免疫学 免疫学 免疫学
- 利皮多米克 (Lipidomics) 是一种消化剂.
背景情况:
- 新兴的二维材料,如六角化 (h-BN) 和化纳米管 (BNNTs),需要了解它们的生物效应,才能安全商业化.
- 评估这些纳米材料对健康和患病细胞的影响至关重要.
研究的目的:
- 研究重复低剂量暴露h-BN和BNNTs对人类支气管上皮细胞 (HBE) 的生物效应.
- 探索对脂质稳定和免疫细胞激活的影响.
主要方法:
- 初级人类支气管上皮细胞 (HBE) 细胞培养暴露于h-BN和BNNTs.
- 进行了全球脂管组学分析.
- 使用了小鼠肺部的体内研究和人类外周血液单核细胞的质量细胞计.
主要成果:
- 暴露于h-BN和BNNTs增加了HBE细胞膜中的脂,脂和二糖含量.
- 在喘HBE细胞和小鼠肺部中,BNNT暴露诱导了脂质媒介生物合成,特别是白血生物合成.
- 来自暴露于BNNT的喘HBE细胞的条件介质激活了表达细胞毒性标记物的淋巴细胞群.
结论:
- BN纳米材料对细胞脂质稳态产生亚细胞毒性作用,并调节免疫反应.
- 这些发现表明潜在的健康危害,特别是对于免疫功能受损的个体,需要仔细考虑BN产品的开发和使用.
相关概念视频
02:26NF-κB-dependent Signaling Pathway
9.7K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
9.7K
01:19Antiasthma Drugs: Leukotriene Modifiers
1.7K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
1.7K