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系统审查与肝癌相关的代谢概况

Bao Le Thai Tran¹, Ngoc Hong Cao¹, Tung Hoang¹

¹Faculty of Pharmacy, University of Health Sciences, Vietnam National University, Ho Chi Minh City, Vietnam.

Journal of liver cancer

|December 2, 2025

概括

代谢分析显示,早期发现肝癌是有前途的. 关键代谢物如氨酸和甲酸与风险增加有关,可以形成诊断模型.

科学领域:

代谢学代谢学代谢学
在瘤学瘤学.
生物标志物发现发现

背景情况:

代谢物越来越多地被认为是它们在肝癌发病过程中的作用.
代谢剖析为早期肝癌检测和诊断提供了潜在的潜力.

研究的目的:

审查早期肝癌诊断代谢分析的文献.
总结代谢物变化并评估基于代谢物模型的诊断性能.

主要方法:

在PubMed,Embase和Web of Science (2004-2024) 的系统文献搜索.
包括96项不同设计的研究 (单个病例,病例控制,队列).
对差异表达代谢物和诊断模型性能 (AUC) 的分析.

主要成果:

氨酸和氨基二氧化醇酸始终与增加肝癌风险有关.
一个10个代谢物模型,包括氨酸和氨基二氧化醇酸,在早期检测方面达到0.86的AUC.
由于样本类型和代谢平台,观察到显著的异质性.

结论:

氨酸和氨基二氧化醇酸在肝癌的发展中起着重要的作用.
代谢分析表现出作为肝癌早期诊断策略的潜力.
未来的研究需要标准化,更大的样本大小和多omics集成,以改善生物标志物的实用性.

关键词:

早期检测早期检测肝癌肝癌是一种肝癌.代谢产物的代谢产物模型的性能模型的性能.系统性审查系统性审查

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