心率变化作为自主功能障碍的标记在患有初级雷诺现象的儿童
Samet Ulusoy1, Gökmen Akgün2, Yunus Emre Bayrak3
1Department of Pediatrics, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
The Turkish journal of pediatrics
|December 2, 2025
概括
患有初级雷诺氏病的儿童
科学领域:
- 儿童心脏病学 儿童心脏病学
- 自主神经系统功能 自主神经系统功能
- 血管生理学 血管生理学
背景情况:
- 初级雷诺氏现象 (RP) 是一种影响儿童的血管动性疾病,可能与自主功能障碍有关.
- 心率变化 (HRV) 分析提供了一种非侵入性方法来评估自主神经系统 (ANS) 活动.
- 了解儿科初级RP中的ANS功能对于阐明疾病机制至关重要.
研究的目的:
- 评估被诊断患有初级雷诺现象的儿童的自主神经系统活动.
- 为了比较儿科初级RP患者和健康对照者之间的心率变化参数.
主要方法:
- 招募了36名初级RP儿童 (0-18岁) 和30名年龄/性别匹配的健康对照组.
- 收集的数据包括人口统计,实验室结果,24小时霍尔特心电图,毛细管镜以及治疗细节.
- 进行了心率变化 (HRV) 的时间和频率域分析.
主要成果:
- 与对照组相比,初级RP患者在所有正常至正常间隔的标准偏差 (SDNN) 和连续差异的标准偏差 (SDSD) 中表现出显著的差异.
- 两组之间连续差异 (RMSSD) 或HRV指数的平方根平均值没有显著差异.
- 毛细管镜检查显示,超过一半的初级RP患者出现了轻微变化;16.6%的人没有自身免疫诊断,但具有积极的抗核抗体.
结论:
- 儿科初级雷诺症现象与自主神经系统功能的显著改变有关.
- 涉及的特定的交感或副交感通路需要进一步调查.
- 多中心,前性研究是必要的,以证实和扩展这些发现.
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