红细胞分布宽度与白蛋白比率和心血管事件在维护血液透析患者中的相关性
Hui Guo1, Fuhua Chen1, Chuchu Zeng1
1Department of Nephrology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, People's Republic of China.
Journal of inflammation research
|December 2, 2025
概括
红细胞分布宽度与白蛋白比率 (RAR) 的增加是维持血液透析 (MHD) 患者心血管事件 (CVEs) 的重要危险因素. 这一比率可能有助于早期发现CVE风险,考虑到性别差异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 临床化学 临床化学
背景情况:
- 维持血液透析 (MHD) 患者面临心血管事件 (CVEs) 的高风险.
- 在MHD患者中确定可靠的CVE风险分层生物标志物至关重要.
研究的目的:
- 调查红细胞分布宽度与白蛋白比率 (RAR) 与MHD患者中CVE发生率之间的相关性.
- 确定RAR是否可以作为CVE的独立预测器.
主要方法:
- 从237名MHD患者的临床数据回顾性收集.
- 使用卡普兰-梅尔生存曲线,考克斯回归模型和受限立方线分析的分析.
- 亚组分析以探索潜在的相互作用效应,例如与性别.
主要成果:
- 在22个月的中位随访期间,42.2%的患者出现了CVEs.
- 较高的RAR被确定为CVE的独立风险因素 (HR=1.336,p=0.005).
- 与最低三位数 (HR=1.909,p=0.028) 相比,RAR三位数最高的患者显示CVE风险显著增加.
结论:
- 红细胞分布宽度与白蛋白比率 (RAR) 是维持血液透析患者心血管事件的独立风险因素.
- 在MHD患者中,RAR可能有助于早期发现心血管事件风险.
- 在使用RAR进行风险评估时,应考虑性别差异.
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