马克辛·希根可以通过抑制α4β7-介导的γδT17细胞在肠-肺-鼻轴上的迁移来缓解肺热综合征
Jingyi Zhao1, Junge Wang1, Xinyu Yan1
1Department of Otolaryngology, Beijing Hospital of Traditional Chinese Medicine, Beijing, People's Republic of China.
Journal of inflammation research
|December 2, 2025
概括
马克辛·希根 (MXSGD) 通过阻断通过CCL25/α4β7通路的γδT17细胞迁移,减少IL-17的产生来治疗肺热综合征 (LHS). 这项研究澄清了LHS和MXSGD中的肠-肺-鼻轴机制.
科学领域:
- 免疫学 免疫学 免疫学
- 传统中国医药 传统中国医药
- 药理学 药理学是指药理学的学科.
背景情况:
- 肺热综合征 (LHS) 是一种涉及肺炎的中国传统医学疾病,缺乏对其肠肺鼻轴参与的机制理解.
- 马克辛·希根 (MXSGD) 在临床上用于LHS,但其免疫调节机制需要阐明.
研究的目的:
- 研究MXSGD在缓解LHS中的免疫调节机制.
- 阐明MXSGD在通过α4β7通路沿肠-肺-鼻轴调节γδT17细胞迁移中的作用.
主要方法:
- 网络药理学和分子对接确定了MXSGD组件和目标.
- 在小鼠中诱导LHS,并用MXSGD治疗.
- 用流细胞计,ELISA和RT-PCR分析了γδT17细胞迁移,CCL25/α4β7通路和IL-17A产生.
主要成果:
- MXSGD缓解了LHS症状,并减少了中性粒细胞透到阴茎和肺部.
- 在肠-肺-鼻轴中,MXSGD抑制了γδT17细胞迁移和IL-17A的产生.
- 鉴定出CCL25/α4β7通路对于LHS的γδT17细胞贩运和IL-17产生至关重要.
结论:
- MXSGD通过抑制CCL25/α4β7依赖的γδT17细胞迁移和IL-17的产生来缓解LHS.
- γδT17细胞贩运中介于LHS的肠-肺-鼻轴相互作用.
- MXSGD显示为IL-17驱动的呼吸道炎症的治疗方法.
相关概念视频
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates these...
01:30Asthma-IV: Diagnostic and Management
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes: