氧化应激和COVID-19严重程度之间的关系:系统性审查和元分析
Mohammad Shah Alam1, Mohammad Nazmol Hasan2, Md Arman Sharif1
1Department of Anatomy and Histology, Gazipur Agricultural University, Gazipur, Bangladesh.
Journal of advanced veterinary and animal research
|December 2, 2025
概括
氧化应激显著影响COVID-19的严重程度. 这项元分析发现,在严重的COVID-19病例中,高氧化剂水平 (过氧化,总氧化应激) 和低氧化剂水平 (超氧化物脱酶,催化酶,谷,硫醇) 较高.
科学领域:
- * 生物化学和分子生物学
- * 免疫学 免疫学
- * 传染病 传染病
背景情况:
- *COVID-19的发病过程涉及SARS-CoV-2,免疫系统和炎症性细胞因子之间的复杂相互作用.
- *氧化应激与这些事件密切相关,并对疾病进展作出重大贡献.
- *了解氧化应激和COVID-19严重程度之间的定量关系对于患者管理至关重要.
研究的目的:
- *在住院患者中量化分析氧化应激标志物与COVID-19疾病严重程度之间的关系.
- * 为了比较不同严重程度组的氧化应激水平:对照组,轻度病例和重度病例.
- * 评估亲氧化剂和抗氧化剂标记在预测COVID-19严重性的作用.
主要方法:
- * 系统地搜索ScienceDirect,PubMed和谷歌学者相关研究的文献.
- *根据随机效应模型使用标准化平均差异 (SMD) 来对17篇选定的文章的数据进行元分析.
- *使用I2统计和埃格尔测试对异质性和偏差的评估.
主要成果:
- *与对照组相比,在轻度和重度的COVID-19病例中观察到显著增加的过氧化 (H2O2) 和总氧化应激 (TOS) 水平.
- * 抗氧化剂标记物,包括超氧化物脱酶 (SOD),催化酶 (CAT),谷氨 (GSH) 和硫醇,在COVID-19患者中显著降低,特别是在严重病例中.
- * 观察到剂量与反应的关系,较高的亲氧化剂和较低的抗氧化剂水平与疾病严重程度的增加相关.
结论:
- * 这一元分析证实,高氧化压力是COVID-19严重性的一个重要因素.
- *在严重的COVID-19病例中,增高的亲氧化剂和减少的抗氧化剂标志物突出显示了它们在疾病发病过程中的作用.
- *监测这些氧化应激标志物可以帮助评估疾病严重程度并优化患者分拣.
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
368
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
368
COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
Coronary Artery Disease I: Introduction
850
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
850
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
Psychoneuroimmunology: Diabetes and Cancer
412
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
412
Physiological Foundation of Stress
518
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
518


