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向临床转化:为FLASH护肤效果建立最佳剂量和剂量速率参数

Yufeng Shen¹, Jie Zhou², Jinyi Lang²

¹Department of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Dose-response : a publication of International Hormesis Society

|December 2, 2025

概括

闪光辐射疗法 (FLASH-RT) 避免了24 Gy以下的皮肤毒性,在250 Gy/s以上的剂量速率下获得最佳保护. 这种方法保持了瘤的控制,同时减少了副作用,为临床翻译铺平了道路.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
临床前研究临床前研究

背景情况:

闪光辐射疗法 (FLASH-RT) 在减少急性辐射毒性方面表现有前途.
在FLASH-RT中需要系统量化剂量和剂量率值,以实现最佳的辐射保护.

研究的目的:

为了确定FLASH-RT中的皮肤节约作用的剂量和剂量率值.
评估FLASH-RT对急性皮肤毒性和抗瘤功效的影响.
为FLASH-RT的临床实施制定指南.

主要方法:

用FLASH-RT (超高剂量速率) 或常规放射治疗 (CONV-RT) 给小鼠的后肢照射单片剂量 (18-24 Gy).
进行了剂量率优化 (40-400 Gy/s) 和再辐射研究.
监测了皮肤损伤,瘤体积,体重,瘤重量和肺转移.

主要成果:

与CONV-RT相比,FLASH-RT在剂量≤22 Gy时显著减少了急性皮肤损伤,但这种效果在≥24 Gy时消失了.
在FLASH-RT剂量率≥300 Gy/s时观察到最佳的皮肤节省.
在重新照射过程中,FLASH-RT实现了与CONV-RT相当的瘤控制,减少了皮肤毒性和肺转移.

结论:

实现FLASH-RT的双门框架:剂量上限<24 Gy和剂量速率门>200 Gy/s (优化>250 Gy/s).
在保持抗瘤功效的同时,FLASH-RT可以最大限度地减少急性皮肤毒性.
这些发现为FLASH-RT.的临床转化提供了指导方针.

关键词:

闪光效应 (FLASH) 是一种闪光效应.急性皮肤毒性急性皮肤毒性再辐射再辐射的方法超高剂量率辐射辐射的超高剂量率辐射.

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