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抗体诱导的PLA2R的内部化和降解放大了CD4+T细胞激活

Yuning Liu1, Yinyin Li1, Hui Zhou1

  • 1Division of Nephrology, Nanfang Hospital, Southern Medical University; State Key Laboratory of Multi-organ Injury Prevention and Treatment; National Clinical Research Center for Kidney Disease; Guangdong Provincial Institute of Nephrology; Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, Guangdong 510515, China.

Theranostics
|December 2, 2025
PubMed
概括

在一次性膜性病 (PMN) 中,抗体与脂酶A2受体 (PLA2R) 结合,引发了其内部化和降解. 这一过程增强了抗原呈现,促进了CD4+ T细胞的激活,并可能维持PMN的自身免疫反应.

关键词:
CD4+ T 细胞是 CD4+ T 细胞.这就是 PLA2R.抗原呈现的呈现方式.克拉林介导的内细胞分裂原发性膜性脏病 - 一次性膜性脏病.

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