多功能巨模仿纳米平台调节血管和上皮双肠屏障,以缓解性结肠炎
Weijian Cheng1, Yixi Zhu1, Miaoxizi Luo1
1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Theranostics
|December 2, 2025
概括
这项研究引入了一种新的纳米粒子治疗方法,可以修复肠上皮屏障和肠道血管屏障,通过减少细菌转移和炎症,为性结肠炎 (UC) 提供一种新的治疗方法.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 胃肠病学 胃肠病学
背景情况:
- 性结肠炎 (UC) 涉及肠上皮屏障 (IEB) 和肠道血管屏障 (GVB) 的损伤.
- 目前的UC治疗主要针对IEB,忽视了GVB在微生物转移中的作用.
- GVB对于防止肠道微生物群和代谢物进入全身循环至关重要.
研究的目的:
- 开发一种仿生纳米粒子战略,用于UC的双重IEB和GVB恢复.
- 用巨细胞膜伪装来设计抗炎性柏柏林/马格诺洛尔纳米颗粒 (BM NPs).
- 调查这些工程NP的目标UC积累和治疗疗效.
主要方法:
- 开发了巨细胞膜伪装的柏柏林/马格诺洛尔纳米粒子 (BM NPs).
- 在试验室中评估了NP向,抗炎作用和血管修复能力.
- 在UC的小鼠模型中评估治疗疗效,测量细菌转位和屏障完整性.
主要成果:
- BM NPs显示在炎症的肠道和血管组织中增强了向和保留.
- 巨细胞膜通过机械引和炎症因子吸附促进了GVB修复.
- 通过NP输送药物修复了IEB,防止了微生物转移,改善了UC病理.
结论:
- 巨细胞膜伪装的NP通过机械和吸附机制提供了IEB和GVB的协同修复.
- 这种方法为UC治疗提供了一个新的范式,通过准两种肠道屏障.
- 该研究强调了恢复双重障碍对于有效管理UC的重要性.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
431
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
431
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
1.0K
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
1.0K
Inflammatory Bowel Disease IV: Pharmacological Management
450
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
450
Inflammatory Bowel Disease I: Ulcerative Colitis
862
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
862
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
461
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
461
Mucosal Barrier of the Stomach
2.0K
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
2.0K


