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卡格里塞马可以降低超重或肥胖成年人的血压: REDEFINE 1
Subodh Verma1,2, Morten Böttcher3, Paul Brown4
1Division of Cardiac Surgery, St. Michael's Hospital of Unity Health Toronto, Li Ka Shing Knowledge Institute, ON, Canada (S.V.).
Hypertension (Dallas, Tex. : 1979)
|December 2, 2025
概括
固定的剂量组合赛马格卢提德/卡格利林提德 (CagriSema) 在超重或肥胖的成年人中显著降低了体重和血压. 这种联合治疗也减少了对抗高血压药物的需求.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖是心血管疾病的主要危险因素,包括高血压.
- 有效的体重管理策略对于改善心血管健康至关重要.
- 固定剂量组合疗法有可能改善患者的坚持和结果.
研究的目的:
- 为了评估在超重或肥胖的成年人中,塞马格卢提德/卡格利林提德 (CagriSema) 的抗高血压作用.
- 评估CagriSema对血压目标和抗高血压药物使用的影响.
- 分析这些影响在各种子组,包括那些有抗性高血压.
主要方法:
- 在REDEFINE 1试验中,3417名没有糖尿病的成年人随机接受了每周一次的CagriSema,semaglutide,cagrilintide或安慰剂,持续了68周.
- 二次和后期分析集中在CagriSema和安慰剂组的血压变化.
- 参与者根据基线BMI,高血压状态和同时使用抗高血压药物进行了分析.
主要成果:
- 与安慰剂相比,CagriSema表现出缩血压 (-10.9 vs -2.8 mm Hg) 和腹缩血压 (-5.4 vs -1.7 mm Hg) 的降低较大.
- 在CagriSema的参与者中,63.0%的人达到血压目标,而安慰剂组的32.0%.
- 在接受卡格里塞马治疗的耐药高血压的参与者中,42.0%的人达到血压目标,39.6%的人减少或停止服用抗高血压药物,而安慰剂患者的比例为18.8%.
结论:
- 塞马格卢提德/卡格利林提德 (CagriSema) 在超重或肥胖的成年人中提供临床显著的血压降低.
- 这些好处扩展到各种各样的子组,包括那些有抗性高血压.
- 卡格里塞马可以减少对抗高血压药物的依赖,支持全面的心血管风险管理.
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