亚洲的脏缩:2025年亚洲脏缩联盟 (ARDeC) 共识声明由高血压心血管结果预防和亚洲证据网络 (HOPE亚洲) 认可
Kazuomi Kario1, Amir Aziz Alkatiri2, Jiro Aoki3
1Department of Cardiovascular Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan (K.K.).
Hypertension (Dallas, Tex. : 1979)
|December 2, 2025
概括
脏缺血 (RDN) 在24小时内有效降低所有测量类型的血压. 这份最新的共识提供了对抗性高血压的RDN的建议,特别有利于夜间高血压的亚洲患者.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 干预心脏病学 干预心脏病学
背景情况:
- 抗性和不受控制的高血压带来了显著的心血管风险,特别是在亚洲人群中,夜间和早晨高血压很普遍,难以管理.
- 目前的抗高血压疗法和生活方式的改变往往不足以使这些患者的血压得到最佳控制.
研究的目的:
- 根据当前的证据和专家的共识,更新对脏皮损伤 (RDN) 的建议.
- 解决亚洲人群高血压管理的具体挑战,包括夜间和早晨高血压.
- 引导RDN在抗性高血压的应用,考虑程序技术和患者选择.
主要方法:
- 参与专家的共识会议,审查现有数据,并为RDN制定更新的指南.
- 专注于现代的RDN技术,以偏远主动脉及其分支为目标.
- 强调了解动脉解剖学和电刺激作为程序终点的潜在作用.
主要成果:
- 在24小时内,RDN显著降低了办公室,家庭和门诊血压.
- 现代的RDN技术专注于偏远的动脉和分支,以有效地准神经.
- 在亚洲常见的夜间和早晨高血压是RDN的潜在目标,因为它24小时有效.
结论:
- 在耐性高血压患者中,RDN是实现最佳的24小时血压控制的有效选择,包括在亚洲普遍存在的夜间或早晨高血压患者.
- 需要进一步的研究来探索RDN反应的种族差异,确定最佳患者候选人,并评估其对器官损伤和心血管事件的长期影响.
相关概念视频
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
888
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
888
Antihypertensive Drugs: Direct Renin Inhibitors
1.2K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.2K
Continuous Renal Replacement Therapy
752
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
752
Antihypertensive Drugs: Angiotensin II Receptor Blockers
2.4K
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
2.4K
Heart Failure V: Medical Management
200
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
200
Renal Regulation of Acid-Base Balance
1.5K
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
1.5K


