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益生菌对酒精性肝病的影响的元分析

Jiadila Bahetiyaer¹, Arafat Md Ferdous², Qing Hong³

¹College of Biological and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China.

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概括

益生菌在治疗酒精性肝病 (ALD) 中表现有前途. 这次元分析发现,益生菌显著降低ALD患者的氨酸转移酶 (ALT) 和酸氨酸转移酶 (AST) 水平.

科学领域:

肝病学肝病学是一种肝病学.
胃肠病学胃肠病学
微生物组研究微生物组研究

背景情况:

酒精性肝病 (ALD) 是一个重大的健康挑战,治疗选择有限.
益生菌在改善ALD患者肝功能中的作用仍在研究中.

研究的目的:

评估益生菌在改善ALD患者肝功能标志物的疗效.
特别关注氨酸氨基转移酶 (ALT) 和其他关键指标,如AST,TB,ALB和GGT.

主要方法:

一个系统的审查和对15个随机对照试验的元分析.
包括酒精性脂肪肝,酒精性肝炎和酒精性肝硬化患者.
在主要的科学文献库中进行全面的数据库搜索.

主要成果:

益生菌疗法显著降低了氨酸转移酶 (ALT) 和酸氨酸转移酶 (AST) 的水平.
没有观察到对总 bilirubin (TB),专蛋白 (ALB) 或 gamma-glutamyl转移酶 (GGT) 水平的显著影响.
在亚洲患者,接受治疗≥8周的患者以及更多男性参与者的子组中,观察到显著的ALT降低.

结论:

益生菌是一种潜在的治疗策略,用于控制ALD患者的ALT水平.
这一元分析支持益生菌作为ALD管理的新方法.

关键词:

这就是ALT ALT.酒精性肝病是一种肝病.我们的肠道微生物群.这是一个元分析.益生菌是一种益生菌.

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