怀孕期间白细胞症和烟草使用
Nayara López Carpintero1,2, Carolina Giráldez-García3, Rodrigo Carmona Camacho4,5
1Department of Obstetrics and Gynecology, Faculty of Biomedical and Health Sciences, Alfonso X el Sabio University, Madrid, Spain.
概括
怀孕期间吸烟显著增加白细胞数量,导致白细胞症在所有三个月. 审查吸烟史和鼓励戒烟对于怀孕时白细胞数量升高的孕妇至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 临床病理学 临床病理学
- 公共卫生 公共卫生
背景情况:
- 怀孕包括改变实验室参数的生理变化.
- 受烟草使用,肥胖和感染等因素影响的促炎症状态可以影响这些参数.
- 白细胞症,即白细胞数量升高,可能是炎症的标志物.
研究的目的:
- 为了在孕妇中识别吸烟诱导的白细胞病,在所有三个季度.
- 提供有助于临床评估吸烟孕妇的数据.
- 了解吸烟对怀孕期间白细胞计数的影响.
主要方法:
- 在WOMAP试验中分析了300名孕妇的人口和实验室数据.
- 评估白细胞数量,中性粒细胞和淋巴细胞百分比,以及血红蛋白/血红素值.
- 逻辑回归用于评估白细胞症和吸烟之间的关联.
主要成果:
- 与非吸烟者相比,吸烟者在所有三季度都有更高的白细胞计数 (P=0.001).
- 血清细胞瘤 (≥10,500/μL) 在所有三季度都与吸烟有显著的关联 (P≤0.014).
- 白血细胞和吸烟之间的关联甚至在考虑肥胖和双重病理时也存在.
结论:
- 怀孕期间的烟草使用与白细胞数量升高和白细胞病变 (leukocytosis) 一致.
- 临床医生应考虑怀孕妇女的吸烟史呈现白细胞症.
- 对于患有白细胞病的孕妇来说,鼓励戒烟至关重要.
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