在结核性脑膜炎中发作的患病率和相关因素
Z Nazleen1, R Rajah2, C S Khoo1,2
1Department of Medicine, Faculty of Medicine, the National University of Malaysia, Kuala Lumpur, Malaysia.
The Medical journal of Malaysia
|December 2, 2025
概括
在结核性脑膜炎 (TBM) 中,发作很常见,影响了近三分之一的患者. 这些发作与更糟糕的神经结果,更高的死亡率有关,并且需要特定的抗药物来管理.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 结核性脑膜炎 (TBM) 是一种严重的结核病形式,具有显著的神经并发症.
- 在TBM患者中,发作带来了诊断和治疗方面的挑战,往往导致不良结果和长时间住院治疗.
研究的目的:
- 为了确定TBM患者中发作的患病率.
- 为了确定与TBM中发作相关的风险因素.
- 为了评估发生的TBM患者的结果.
主要方法:
- 一项追溯观察性研究,涉及96名成年TBM患者.
- 患者被分为发作和非发作组.
- 分析包括临床,实验室,放射和治疗变量,以及抗发作药物的使用和神经结果.
主要成果:
- 发作发生在30.2%的TBM患者中,一般性发作是最常见的.
- 发作患者在入院时表现出更多的行为变化,焦点神经缺陷和更低的格拉斯哥昏迷表得分.
- 发作患者的死亡率较高 (27.6%) 和功能结果较差.
结论:
- 发作在TBM中很普遍,并且与更糟糕的临床和神经学结果有显著的关联.
- 改变行为和焦点缺陷可能表明TBM患者的发作风险较高.
- 常见的抗发作药物包括芬伊托因,氨酸和 levetiracetam;为了优化管理,需要进一步的研究.
相关概念视频
Pulmonary Tuberculosis I
806
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
806
Epilepsy and Seizures: Overview
1.1K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.1K
Seizures: Classification
1.3K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.3K
Pulmonary Tuberculosis III
899
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
899
Pulmonary Tuberculosis IV
468
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
468
Pulmonary Tuberculosis II
1.3K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.3K


