在COVID-19中,MUC5AC基因表达具有鼻症状的鼻分泌物
D Irfandy1, A Afriwardi2, E P Andani3
1Universitas Andalas/Dr. M. Djamil General Hospital, Faculty of Medicine, Department of Otorhinolaryngology, Division of Rhinology, Padang, Indonesia. dollyirfandy@med.unand.ac.id.
The Medical journal of Malaysia
|December 2, 2025
概括
鼻分泌物中MUC5AC表达的增加与COVID-19感染有关,尽管患者中鼻 (流鼻水) 症状的发生率较低. 这一发现突出了呼吸系统疾病的潜在生物标志物.
科学领域:
- * 呼吸系统医学 呼吸系统医学
- * 传染病 传染病
- * 分子生物学 * 分子生物学
背景情况:
- *由SARS-CoV-2引起的2019年冠状病毒病 (COVID-19) 是一个重要的全球健康问题,全球有数百万病例和死亡.
- * 虽然流鼻在流感和普通感冒中很常见,但它仅在COVID-19病例中的4%中出现.
- *COVID-19会影响鼻上皮质,引发免疫反应并改变保护性糖蛋白的产生,如粘素.
研究的目的:
- * 调查鼻分泌物中MUC5AC表达水平与COVID-19感染的存在之间的联系.
- *分析MUC5AC作为COVID-19诊断中的潜在指标.
主要方法:
- * 具有横截面设计的分析研究.
- *使用80名参与者 (40名COVID-19阳性,40名阴性) 通过RT-qPCR确认的储存的鼻子拭子样本.
- *采用简单的随机抽样,并使用独立的学生t-test分析数据.
主要成果:
- *该研究包括58%的女性和42%的男性在COVID-19阳性病例中.
- *只有22%的COVID-19阳性个体报告经历了流鼻症状.
- *在COVID-19患者中观察到MUC5AC相对表达的9.77倍显著增加.
结论:
- *MUC5AC表达在COVID-19患者的鼻分泌物中显著升高.
- *该研究观察到MUC5AC水平增加与COVID-19患者鼻发病率低之间存在差异.
- *MUC5AC可能作为COVID-19的潜在生物标志物,无论具体的症状呈现如何.
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