冲动失控症状与主观认知衰退和轻度认知障碍患者的氨基酸β有关
Ana Luiza Gonçalves Rochetti1, Isadora Cristina Ribeiro1, Lucas Luchesi Barnes1
1School of Medical Sciences, UNICAMP/SP, Campinas, Brazil.
概括
这项研究发现,在巴西的轻度认知障碍或主观认知衰退的个体中,冲动性症状和粉样蛋白病理之间存在联系. 这些发现突显了神经精神症状与阿尔茨海默病生物标志物之间的关系.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 神经退行性疾病 神经退行性疾病
背景情况:
- 神经精神症状 (NPS) 和阿尔茨海默病 (AD) 病理生理学之间的联系,特别是在主观认知衰退 (SCD) 和轻度认知障碍 (MCI) 等早期阶段,仍然不清楚.
- 现有文献中的相互矛盾的发现需要进一步调查AD生物标志物的AD生物标志物在NPS发展中的作用.
- 了解这些关系对于在AD连续体内开发有效的纵向干预措施至关重要.
研究的目的:
- 在被诊断患有SCD和MCI的巴西人中调查NPS和脑脊液 (CSF) AD生物标志物之间的相关性.
- 澄清阿尔茨海默氏症生物标志物在阿尔茨海默氏症早期,前期阶段NPS出现中的作用.
主要方法:
- 采用横截面研究设计来评估SCD和MCI患者中NPS和CSFAD生物标志物之间的关系.
- 参与者 (年龄≥55) 接受了全面的医学和神经心理评估,包括认知评估 (MoCA) 和功能活动问卷 (Pfeffer的常见问题).
- 排除标准确保了一个均的研究组,不包括患有痴呆症,其他神经/精神疾病或显著的脑血管变化 (法泽卡斯尺度≥2) 的个人.
主要成果:
- 在2019年至2022年期间进行的研究中,包括71名参与者 (54名MCI,17名SCD).
- 在多维身体自我关系问卷 - 外观尺度 (MBIS-C) 的C域和CSF粉样β度之间确定了统计学上显著的相关性 (p=0.006).
- 这一发现表明,特定的神经精神症状 (如冲动性) 与粉样蛋白病理存在之间存在潜在联系.
结论:
- 该研究确定了冲动性 (MBI-C域C) 和脑液β-粉样蛋白水平在SCD和MCI的巴西患者之间存在显著的关联.
- 这些结果支持了将冲动性作为神经精神病症状与阿密洛伊德病理在阿尔茨海默氏症早期阶段联系在一起的假设.
- 需要进一步的研究来探索各种神经精神症状,MBI和AD CSF生物标志物之间的复杂相关性.
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