在FIGO 2023期IC期子宫内膜癌中进行辅助性放射治疗
Alper Kahvecioğlu1, Sezin Yüce Sarı1, Melis Gültekin1
1Hacettepe University Faculty of Medicine, Department of Radiation Oncology, Ankara, Türkiye.
Turkish journal of obstetrics and gynecology
|December 2, 2025
概括
辅助放射疗法 (RT) 对IC期子宫内膜癌显示出有利的结果. 然而,恶性腹细胞学表明预后不佳,这表明需要在这个亚组加强治疗.
科学领域:
- 妇科瘤学 妇科瘤学
- 辐射瘤学 辐射瘤学
- 病理学 病理学 病理学
背景情况:
- 宫内膜癌的分期对于治疗计划至关重要.
- 根据FIGO 2023框架,IC阶段的子宫内膜癌涉及到仅限于子宫内膜的侵略性组织学,没有肌膜入侵.
- 辅助放射治疗 (RT) 是这个阶段的常见治疗方式.
研究的目的:
- 为了评估与辅助RT治疗的FIGO 2023期IC子宫内膜癌患者的治疗结果和存活率.
- 为了确定影响该患者队列生存的预后因素.
主要方法:
- 对28名患有FIGO 2023阶段IC子宫内膜癌的患者进行了回顾性分析,这些患者接受了辅助RT.
- 数据收集包括组织学亚型,治疗方案 (单独RT与化疗RT),RT技术和生存结果.
- 统计分析的重点是整体存活率 (OS),局部区域无复发存活率 (LRRFS) 和远程无转移存活率 (DMFS).
主要成果:
- 血清癌是最常见的亚型 (39%).
- 大多数 (86%) 接受了阴道支臂疗法.
- 两年期和五年期的OS率分别为96%和87%. 两年期和五年期LRRFS的利率分别为96%和82%. 2年和5年的DMFS率分别为92%和80%.
- 恶性腹细胞学是OS,LRRFS和DMFS的显著不良预后因素.
- 没有观察到严重的毒性,并且在RT中添加化疗并没有在这个队列中显示出明显的生存益处.
结论:
- 辅助性RT与IC阶段子宫内膜癌的良好结果有关.
- 恶性腹细胞学是这个群体中一个关键的不良预后指标.
- 对于患有恶性周周细胞学的患者,可能需要考虑加强辅助疗法,例如组合化疗.
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