口腔微生物群多样性在细胞核上很重要,在慢性乙型肝炎中类似的终止
Mahin Ghorbani1, Agne Kvedaraite1, Khaled Al-Manei1,2
1Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.
The Journal of infectious diseases
|December 2, 2025
概括
口腔微生物组分析可以预测慢性乙型肝炎 (CHB) 患者停止核酸类比 (NUC) 治疗的结果. 更高的口腔微生物多样性与CHB中NUC停止后的良好结果有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 微生物组研究 微生物组研究
- 病毒学 病毒学
背景情况:
- 在HBeAg阴性慢性乙型肝炎 (CHB) 中,取消核酸模拟 (NUC) 治疗为功能治愈提供了潜力.
- 肠道微生物组在CHB进展和治疗中的作用已知,但在NUC停止期间口腔微生物组的影响尚未被探索.
研究的目的:
- 为了研究HBeAg阴性CHB患者的口腔微生物组合,这些患者正在进行计划的NUC停止.
- 为了确定口腔微生物组资料是否可以预测NUC撤销后的病毒学结果.
主要方法:
- 一项纵向研究分析了来自18名HBeAg阴性CHB患者的110个唾液样本,持续了36个月,并计划停止NUC.
- 评估了口腔微生物组组成的七个时间点.
- 良好的结果是由HBsAg损失,HBVDNA显著下降或治疗后持续低的HBVDNA定义的;肝炎是由ALT水平定义的.
主要成果:
- 与不良结果患者相比,具有有利结果的患者表现出更高的口腔微生物α多样性 (香农,辛普森指数) 和较低的样本间变异 (布雷-库蒂斯,贾卡德距离).
- 特定的Prevotella种类与HBsAg,ALT和AST水平相反相关.
- 机会性种类如Haemophilus parainfluenzae和Porphyromonas catoniae与不利的结果和高的HBsAg水平有关.
- 使用口腔微生物群标记物的预测模型在预测结果方面表现优于临床标记物 (AUC 0.78 与 0.66).
结论:
- 在HBeAg阴性CHB患者的NUC终止时口腔微生物组分析可能有助于预测病毒学结果.
- 特定的口腔微生物特征可以作为预测NUC撤销后治疗成功的生物标志物.
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