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Updated: Jan 9, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
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Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

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DUX4诱导的HSATIIRNA积累驱动蛋白质聚合,影响RNA处理途径

Tessa Arends1, Sean R Bennett1, Stephen J Tapscott1,2,3

  • 1Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

The Journal of cell biology
|December 2, 2025
PubMed
概括

双同源盒4 (DUX4) 通过诱导核内RNAs,驱动蛋白质聚合并改变肌肉细胞中的RNA处理,导致肌肉骨骨肌肉缩 (FSHD).

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siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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