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补充激活与慢性鼻炎患者的鼻息肉的嗅觉功能受损相关

Sufiya Ali¹, Alexander O Johnson¹, Maria Villanueva¹

¹Department of Otolaryngology-Head & Neck Surgery, University of Florida, Gainesville, Florida.

Chemical senses

|December 2, 2025

概括

增高的补体激活,特别是通过莱克和替代途径,与慢性鼻炎与鼻息肉 (CRSwNP) 中恶化的嗅觉功能障碍有关. 这表明补充剂在嗅觉丧失中起着作用.

科学领域:

免疫学免疫学免疫学
耳鼻喉科耳鼻喉科耳鼻喉科
补充系统生物学补充系统生物学

背景情况:

慢性鼻炎与鼻息肉 (CRSwNP) 中嗅觉损失的机制尚不清楚.
之前的研究表明,较高的C3补充成分水平与CRSwNP严重程度相关.
补充系统在视觉和听觉感官损伤中的作用是已知的,但其对嗅觉的影响尚未被探索.

研究的目的:

研究补体系统途径在与CRSwNP相关的嗅觉功能障碍中的参与.
评估CRSwNP患者的嗅觉裂粘液中的补充蛋白和激活片段水平.
为了将补充激活与嗅觉障碍的严重程度相关联.

主要方法:

嗅觉裂粘液从22名接受内镜外科手术的CRSwNP患者中收集.
使用宾夕法尼亚大学气味识别测试 (UPSIT) 评估了嗅觉状态.
用多重测定和ELISA测量了各种补充通路蛋白质,激活片段和调节者的度.

主要成果:

患有嗅觉功能障碍的CRSwNP患者表现出更高的MBL,C4,C3,fB和阿迪普辛水平,表明了莱克和替代途径的激活.
通过C3a和C3b碎片证明的补体激活增加,在中度至全的患者中显著更高.
观察到补充抑制剂H因子的水平升高,与补充活性增加相关.

结论:

补体激活升高与CRSwNP中更严重的嗅觉功能障碍显著相关.
莱克和替代补充通路似乎参与了与CRSwNP相关的气味丧失的致病性.
这些发现突显了补充通路在CRSwNP中嗅觉障碍的潜在治疗目标.

关键词:

慢性鼻炎是什么意思慢性鼻炎嗅觉障碍嗅觉障碍嗅觉障碍嗅觉障碍嗅觉障碍这是一个UPSITUPSITUPSIT.嗅觉嗅觉是一种嗅觉.鼻炎是一种鼻炎.

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