在接受血造干细胞移植的患者体育炼的影响:系统性审查和元分析
Carlos Martín-Sánchez1,2, Luis Polo-Ferrero1,2, Mónica Baile-González3,4
1Faculty of Nursing and Physiotherapy, Department of Nursing and Physiotherapy, University of Salamanca, Salamanca, Spain.
概括
身体炼显著改善了血液形成干细胞移植后的患者的功能能力和下肢力量. 较长的炼计划可以提高恢复,减少疲劳.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 康复医学 康复医学 康复医学
- 运动生理学 运动生理学
背景情况:
- 造血干细胞移植 (HSCT) 是各种血液恶性瘤和其他疾病的关键治疗方法.
- 接受HSCT的患者经常体验身体功能显著下降,包括生活质量 (QoL) 降低,有氧能力,疲劳增加和肌肉疲弱.
- 优化移植后恢复和长期结果需要有效的康复策略.
研究的目的:
- 系统地评估体育炼干预措施对接受HSCT的患者关键临床结果的影响.
- 评估运动对生活质量 (QoL),有氧能力,疲劳程度和肌肉力量的影响.
- 通过元分析来综合证据,以确定运动在这个患者群体中的有效性.
主要方法:
- 根据PRISMA指南进行了全面的系统审查和元分析.
- 在主要数据库 (PubMed,Embase,Cochrane图书馆,科学网,Scopus) 进行了搜索,截至2025年4月.
- 方法质量和偏差风险分别使用佩德罗尺度和ROB2.0工具进行评估.
主要成果:
- 分析包括7项研究,总共综合了20项研究的数据.
- 运动在改善功能能力方面表现出显著的中等效果 (SMD = 0.43,p = 0.002) 和在下肢力量方面表现出很大的显著效果 (SMD = 1.48,p < 0.001).
- 对 QoL (SMD = 0.23,p = 0.072),疲劳 (SMD = -0.05,p = 0.819) 和手握强度 (SMD = 0.21,p = 0.201) 的影响没有统计学意义,尽管更长的干预持续时间与更大的疲劳改善相关.
结论:
- 在HSCT后,体育炼干预措施有效提高功能能力和下肢力量.
- 运动对生活质量和疲劳的影响不那么一致,这表明需要量身定制或延长的计划.
- 建议进行长时间的运动计划,以优化恢复,并可能减轻HSCT患者的疲劳.
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