基于DNA甲基化的表观遗传时钟突出显示了COVID-19在不同人群中免疫驱动的衰老加速
Manoj Kumar Gupta1, Ramakrishna Vadde2
1Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, 516005, Andhra Pradesh, India. mkgupta.bioinfo@gmail.com.
Biogerontology
|December 2, 2025
概括
由于免疫调节失调,COVID-19加速表观遗传衰老,特别是在老年和女性患者中. 下一代表观遗传时钟显示加速衰老,与第一代时钟不同,突出了对感染相关变化的差异敏感性.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
- 病毒学 病毒学
背景情况:
- 老龄化是严重的COVID-19结果的一个重要风险因素.
- 通过DNA甲基化测量表观遗传衰老,为生物学衰老提供了洞察力.
- 了解COVID-19中的表观遗传变化对于评估疾病严重程度至关重要.
研究的目的:
- 与健康个体相比,研究COVID-19患者表观遗传衰老的速度.
- 评估各种表观遗传钟在反映COVID-19相关衰老方面的表现.
- 探索在COVID-19中免疫失调和加速表观遗传衰老之间的关系.
主要方法:
- 利用DNA甲基化数据计算多个表观遗传衰老标记 (钟).
- 在COVID-19患者和健康对照者之间比较表观遗传年龄加速.
- 分析了表观遗传衰老,时间年龄,性别,种族和免疫标记之间的相关性.
主要成果:
- 下一代钟表 (例如PCGrimAge,DunedinPACE) 显示COVID-19患者的衰老加速,特别是老年人和女性.
- 第一代时钟 (例如,Hannum2013) 显示衰老减少,表明检测感染相关变化的局限性.
- 免疫失调,反映在年龄加速 (AA) 和外部表观遗传年龄加速 (EEAA) 中,是加速衰老的强大驱动力,而不是内在表观遗传年龄加速 (IEAA).
- 在欧洲和非欧洲COVID-19患者之间观察到内在表观遗传年龄加速 (IEAA) 的差异.
结论:
- 下一代表观遗传钟对COVID-19相关的生物变化比第一代钟更敏感.
- 在COVID-19中加速表观遗传衰老主要与免疫失调有关.
- 表观遗传时钟的敏感性有所变化,需要对研究与感染相关的衰老进行仔细选择.
更多相关视频
相关概念视频
Epigenetic Regulation
3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.7K
Epigenetic Regulation
33.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
Aging
552
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
552
Replication in Eukaryotes
16.9K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
16.9K
The Effect of Aging on Tissues
3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
Circadian Rhythms and Gene Regulation
4.5K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K


