二级运动皮层-外部环球皮管道调节了意志控制的听觉反
Shengtao Luo1,2,3, Yuchen Fan1,2, Feiyang Yu1,2
1The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Neuroscience bulletin
|December 2, 2025
概括
大脑-计算机接口 (BCI) 需要意志抑制来实现适应性控制. 使用听觉生物反的M2-GPe途径增强了这种控制,提高了BCI的疗效.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 生物工程是生物工程.
背景情况:
- 有效的脑电脑接口 (BCI) 依赖于意志抑制,即抑制计划行动的能力.
- 在现实应用中适应性控制至关重要的意志抑制背后的神经机制仍然不完全理解.
研究的目的:
- 在小鼠中使用停止信号任务调查M2-GPe通路在意志抑制中的作用.
- 探索调节M2-GPe通路如何影响神经活动和行为抑制.
主要方法:
- 纤维光度测量用于监测小鼠外部白色球体 (GPe) 和亚体核 (STN) 中的神经元活动.
- 采用了随意的停止信号任务,使用听觉线索和反.
- 化学遗传学和光遗传学被用来操纵M2-GPe通路活性.
主要成果:
- GPe和STN神经元对听觉线索,反和奖励做出了反应.
- 激活M2-GPe通路通过调节听觉反反应来增强意志抑制.
- 在听觉反时抑制M2投射GPe神经元也改善了意志抑制,延长了GO试验反应时间.
结论:
- M2-GPe通路被确定为在意志控制中用于听觉生物反的关键神经电路.
- 准M2-GPe通路为推进神经接口和提高BCI有效性提供了潜力.
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