身体活动和阿尔茨海默病风险跨越遗传易感性:一个前性英国生物库研究使用加速仪数据
Seunghee Na1, Kenneth Muir2, Artitaya Lophatananon2
1Department of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Journal of neurology
|December 2, 2025
概括
定期的体力活动 (PA) 显著降低了阿尔茨海默病 (AD) 的风险,无论遗传倾向如何. 即使是光强度的运动也提供了实质性的保护,使PA成为AD预防的通用策略.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 身体活动 (PA) 与降低阿尔茨海默病 (AD) 风险有关.
- 以前的研究由于自我报告的PA和简化的遗传模型而面临限制.
- 在AD的不同遗传风险水平上,PA的影响需要进一步调查.
研究的目的:
- 调查加速度计测量PA和事件AD风险之间的关联.
- 探索PA和AD多基因风险评分 (PRS) 之间的潜在相互作用.
- 为了确定PA的保护作用是否基于遗传AD风险而有所不同.
主要方法:
- 分析了93578名英国生物库参与者 (年龄在40-70岁之间) 的加速度计和基因定型数据.
- 持续测量PA (毫克重量,毫克) 和二分化;通过PRS和APOE ε4状态评估遗传风险.
- 考克斯模型用于估计发生阿尔茨海默病的危险比率,随访时间中位数为15.5年.
主要成果:
- 高血压与降低48%的AD风险相关 (HR0.517).
- 高PRS几乎增加了AD风险的两倍 (HR 2.423),但PA的保护作用在所有遗传风险层中是一致的.
- 没有发现PA和遗传风险之间的显著相互作用;光强度活动 (≥21.7毫克) 提供了最大的益处.
结论:
- 客观测量PA显著降低AD风险,独立于一个人的遗传倾向.
- 光强度的体力活动提供了对AD的有意义的保护.
- 抗阿尔茨海默病是一种广泛适用的预防策略,适用于所有阿尔茨海默病遗传风险水平的个人.
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