肠道和肠外恶性病的风险在炎症性肠道疾病中,有或没有初级硬化胆管炎
Omar Al Ta'ani1, Saqr Alsakarneh2, Aasma Shaukat3
1Department of Medicine, Allegheny Health Network, 320 E N Ave, Pittsburgh, PA, 15212, USA. otaani19@gmail.com.
Digestive diseases and sciences
|December 2, 2025
概括
患有同时存在的炎症性肠病和原发性硬化性胆管炎 (IBD-PSC) 的患者面临的癌症风险明显高于那些单独患有IBD或PSC的患者. 这凸显了针对IBD-PSC患者进行向癌症查的迫切需要.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
背景情况:
- 原发性硬化性胆管炎 (PSC) 是一种慢性肝病,经常与炎症性肠病 (IBD) 一起发生.
- 无论是PSC还是IBD,都会单独增加癌症风险.
- 与单独的IBD或PSC相比,患有两种疾病 (IBD-PSC) 的患者的综合癌症风险尚不清楚.
研究的目的:
- 将IBD-PSC患者的癌症负担与IBD和PSC患者的癌症负担进行比较.
- 在IBD-PSC人群中识别具有高风险的特定癌症类型.
主要方法:
- 使用TrinetX电子健康记录数据库进行回顾性队列研究.
- 倾向性得分匹配 (PSM) 以平衡IBD-PSC,孤立IBD和孤立PSC组之间的基线特征.
- 对肠道和肠外恶性瘤的调整危险比率 (aHR) 的计算.
主要成果:
- 与孤立IBD相比,IBD-PSC患者的结直肠癌,胆管癌,肝癌,胰腺癌和胆囊癌的风险显著增加.
- 与孤立的PSC相比,IBD-PSC患有结直肠和胆囊癌的风险更高.
- 具体的aHR强调IBD-PSC多重恶性瘤的风险大幅增加.
结论:
- 同时存在的IBD和PSC (IBD-PSC) 与肠道和肠外恶性瘤的风险大幅增加有关.
- 这些发现表明IBD和PSC之间的协同致癌效应.
- 针对性监测和早期检测策略对于高风险IBD-PSC人群至关重要.
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