肠道微生物群概况,潜在的工程技术及其对家禽健康的遗传和表观遗传影响
Nuruliarizki Shinta Pandupuspitasari1,2, Sugiharto Sugiharto3, Faheem Ahmed Khan4
1Animal Science Department, Faculty of Animal and Agricultural Sciences, Universitas Diponegoro, Semarang, 50275, Indonesia. shin_tse@yahoo.com.
World journal of microbiology & biotechnology
|December 2, 2025
概括
工程家禽肠道微生物群提高了动物健康和产品质量,为抗生素增长促进剂提供了可持续的替代品. 这种方法优化了营养吸收和免疫功能,改善了家禽生产.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 肠道健康 肠道健康
背景情况:
- 家禽产品是全球重要的粮食资源.
- 肠道微生物群显著影响家禽的健康,新陈代谢和免疫力.
- 抗生素增长促进剂对肠道微生物群和家禽的可持续性产生负面影响.
研究的目的:
- 探索肠道微生物群工程,作为禽类抗生素增长促进剂的替代品.
- 研究肠道微生物群在营养利用和宿主基因表达中的作用.
- 了解潜在的个性化治疗的双向宿主微生物群相互作用.
主要方法:
- 在家禽中分析肠道微生物群的组成和功能.
- 研究微生物代谢物,包括短链脂肪酸 (SCFA).
- 检查受微生物代谢物影响的宿主基因表达.
主要成果:
- 肠道微生物群工程改善了家禽的健康和免疫反应.
- 像SCFA这样的微生物代谢物以表观遗传学方式调节宿主基因表达.
- 微生物群调节可以提高家禽肉和蛋的质量和数量.
结论:
- 工程肠道微生物群是一种安全有效的替代抗生素增长促进剂.
- 优化肠道微生物群促进了可持续的家禽生产.
- 对宿主微生物群相互作用的进一步研究可能会导致个性化的家禽治疗.
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