手术对仅有骨转移的TNBC生存的影响:与倾向性得分匹配的SEER数据库分析
Shengbin Cai1, Qiran Lu1, Luxin Wei1
1General Surgery Ward, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, No. 9 Chongwen Road, Suzhou, Jiangsu Province, 215006, People's Republic of China.
Discover oncology
|December 2, 2025
概括
主要部位手术可以改善三阴性乳腺癌 (TNBC) 和骨转移的女性的生存率. 将手术与全身治疗相结合为这些患者提供了最好的结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 三重阴性乳腺癌 (TNBC) 预后不好,经常转移到骨.
- 初级瘤切除在TNBC患者骨转移的生存益处仍然存在争议.
- 这项研究调查了手术在TNBC中与孤立骨转移的作用.
研究的目的:
- 评估初级部位手术对TNBC骨转移患者的生存结果的影响.
- 为了比较接受初级部位手术的患者和没有接受初级部位手术的患者之间的生存率.
- 确定TNBC患者骨转移的最佳治疗策略.
主要方法:
- 从SEER数据库对435名TNBC患者的骨转移在诊断时进行了回顾性分析.
- 倾向性得分匹配 (PSM) 用于尽量减少手术和非手术组之间的偏差.
- 为了确定预后指标,进行了单变量,多变量和逐步回归分析.
主要成果:
- 在PSM之后,每个组中有126名患者 (手术与非手术).
- 主要部位手术与明显更长的整体生存期 (OS) 和因果特定生存期 (CSS) 相关.
- 与全身治疗相结合的手术显示出比单独手术更好的结果;扩大手术范围没有改善OS或CSS.
结论:
- 只有骨转移的TNBC患者的初级部位手术与没有手术相比,与改善的OS和CSS有关.
- 手术和全身治疗的结合方法是首选的治疗选择.
- 针对原发性瘤的手术干预可以在某些具有骨转移的TNBC患者中有益.
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