抗肌肉素的使用和痴呆症发病率在女性过度活跃的膀
Caitlyn E Painter1, Douglas Stram2, Victor S Velasco2,3
1Division of Urogynecology, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco.
Urogynecology (Philadelphia, Pa.)
|December 2, 2025
概括
过度活性膀 (OAB) 抗糖药物与老年女性痴呆和认知障碍 (DCI) 风险增加有关. 对这些药物的累积暴露较高加剧了这种关联,即使考虑到年龄和健康状况.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
背景情况:
- 抗肌糖药物经常被处方用于过度活跃的膀 (OAB).
- 新出现的证据表明,抗木斯卡林的使用与认知衰退之间存在潜在的联系,包括痴呆症和认知障碍 (DCI).
- 这引发了人们对抗肌肉抗药物用于管理OAB的长期安全性的担忧.
研究的目的:
- 为了确定患有OAB的女性中DCI的发病率.
- 调查OAB抗糖药物的使用是否与DCI的风险增加有关.
- 量化累积抗肌肉素暴露与DCI发展之间的关系.
主要方法:
- 进行了一项回顾性队列研究,涉及诊断为OAB的55岁及以上的女性.
- 参与者被分为抗肌糖药使用者和非使用者,随访期至少为10年.
- 使用国际疾病分类代码识别了事件DCI,并使用后勤回归来分析与抗肌肉素使用和累积暴露的关联.
主要成果:
- 在16,249名女性中,7.4%被诊断为DCI,44%使用抗肌肉药物治疗OAB.
- 患有DCI的女性年龄较大,患病并发症较多,更有可能使用抗肌糖药,表现出较高的抗胆固醇负担得分.
- 多变量分析显示,OAB诊断时的年龄,糖尿病和膀抗肌糖药的使用与发生的DCI有显著的相关性.
结论:
- 在患有OAB的女性中,DCI与膀抗肌肉药的使用有关.
- 对抗肌肉类药物的累积暴露较高与DCI的发病率增加有关.
- 这种关联即使控制了诸如年龄和并发性疾病等混因素,仍然很重要.
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