斯德哥尔摩县双胞胎怀孕中的死产 2000-2021-一项描述性研究
Matilda Varli Hjärne1, Cecilia Pegelow Halvorsen1,2, Hanna Åmark1,3
1Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
PloS one
|December 2, 2025
概括
在双胞胎怀孕中,死胎的风险更高,特别是由于双胞胎对双胞胎输血综合征 (TTTS) 的单双胞胎. 双双胞胎死产导致镜像单子死产,随着时间的推移,发生率下降.
科学领域:
- 围产期流行病学 围产期流行病学
- 孕产妇和胎儿的医学
- 生殖健康 生殖健康
背景情况:
- 双胞胎怀孕的死亡率高于单独怀孕的死亡率.
- 已知的危险因素包括选择性胎儿生长限制,双胞胎对双胞胎输血综合征 (TTTS) 和孕前.
- 双胞胎怀孕中死产的综合风险因素和原因需要进一步探索.
研究的目的:
- 为了确定双胞胎怀孕中死产的发生率.
- 为了确定相关的风险因素和死产的原因.
- 基于胆管性和双胞胎和单胞胎死产之间的怀孕特征进行比较.
主要方法:
- 一个描述性的,基于注册的队列研究.
- 包括1978年斯德哥尔摩县的单胎和193例双胞胎死产 (2000-2021年).
- 来自斯德哥尔摩死产组和瑞典怀孕登记册的数据;根据胆管和单独死产进行比较.
主要成果:
- 双胞胎怀孕的死胎发生率高于单子怀孕,两者随着时间的推移都在下降.
- 双胞胎死胎发生在怀孕早期,与单独死胎相比,胎儿的出生体重较低.
- 双胞胎双胞胎死产与TTTS有很强的联系;双胞胎双胞胎死产的原因类似于早产单胞胎死产 (胎盘缺陷,胎儿生长限制).
结论:
- 双胞胎怀孕中死产的风险是单胎怀孕的两倍多,尽管发病率有所下降.
- 双胞胎对双胞胎输血综合征 (TTTS) 是单胞胎双胞胎死产的重要危险因素.
- 双双胞胎死产的原因与早产单子死产的原因相似.
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