结构化个性化氧气和支持性治疗喘在瘤学 (SPOT-ON):一个个性化的随机临床试验协议
David Hui1,2,3, Min Ji Kim1, Saji Thomas4
1Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
PloS one
|December 2, 2025
概括
这项研究研究了个性化呼吸治疗师主导的干预 (SPOT-ON) 与用于缓解住院癌症患者呼吸障碍的常规护理,使用低流量补充氧气 (LFSO),高流量鼻管 (HFNC) 和非侵入性通风 (NIV). 调查结果将指导个性化呼吸困难管理.
科学领域:
- 抚慰性护理是一种缓解性护理.
- 呼吸系统医学 呼吸系统医学
- 临床试验 临床试验
背景情况:
- 住院的癌症患者经常经历呼吸障碍,这是一个令人痛苦的症状,需要有效的管理.
- 低流量补充氧 (LFSO),高流量鼻腔管 (HFNC) 和非侵入性通风 (NIV) 是呼吸障碍的常见息治疗方法.
- 根据患者的偏好,对这些呼吸支模式的最佳个性化仍然不清楚.
研究的目的:
- 为了比较个性化呼吸治疗师 (RT) 带领的干预 (SPOT-ON) 与增强的常规护理,以减少住院癌症患者的呼吸障碍强度.
- 根据个体患者的偏好来评估定制LFSO,HFNC和NIV设置和使用的有效性.
主要方法:
- 一个双臂,并行组,等候名单控制的随机临床试验,涉及150名住院的晚期癌症患者呼吸障碍 (NRS ≥4).
- 患者被随机分为1:1接受即时SPOT-ON干预或72小时等候名单控制.
- 该SPOT-ON干预包括LFSO,HFNC和NIV的时间有限试验,随后在72小时内进行个性化部署.
主要成果:
- 主要结局:呼吸障碍数值评分表 (NRS) 强度的变化,从基线到24小时.
- 二级结局:呼吸障碍不愉快,生命体征,症状负担,生活质量,不良事件和医院结局.
- 该研究的动力用于检测NRS强度的1.2点差异.
结论:
- 这项试验可以为个性化使用氧气和支持癌症患者呼吸障碍缓解的方法提供信息.
- 针对个性化治疗使用时间有限试验的新方法论可能会指导未来的支持性护理试验设计.
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